January 15,
image of Dr. Nadine Pernodet
Why are sirtuins exciting or important?

Dr. Pernodet: After sirtuins were discovered, there was a rise of interest when they were reported to be linked to lifespan. These proteins have also been found to be present at a higher level in people 100 or more years old. We at Estée Lauder have now been studying the role of sirtuins in skin for over 15 years.

We started by studying SIRT-1 in collaboration with Dr. Guarente’s lab from The Massachusetts Institute of Technology, who made the primary discoveries on sirtuins. This work showed that SIRT-1 helps to promote the skin barrier, plus additional research at Estee Lauder laboratories showed SIRT-1 helps to support skin’s natural repair.

Further studies in partnership with Harvard scientists demonstrated that SIRT-3 helps support natural skin energy. Our interest in Sirtuins expanded and we began to focus on SIRT-6, by developing models to better understand its critical role in skin and its connection to skin soothing.

We did the same for SIRT-2. We have been on the forefront of its research proving how it can impact skin’s natural lifting ability.

Taken together, we understand how each of them supports youthful skin.

What sirtuin research are you working on now? What does the future hold?

Dr. Pernodet: We continue to research and learn how SIRTs impact skin aging and leverage these learnings as we develop powerful technologies to help counter the visible signs of skin aging.

What are your hopes for sirtuins? What’s the ultimate goal?

Dr. Pernodet: The research we’ve done shows that sirtuins are related to skin’s youthful skin texture and tone, its youthful structure and elasticity. As this research is still early, we will continue and hope to unlock further secrets from sirtuins and leverage these findings to positively impact the look of skin!

We think there are many more opportunities and hope that our future research continues to identify additional knowledge and benefits about the role of sirtuins in skin. This helps us in our ultimate goal of always pushing to develop skincare founded on science and formulated with advanced technologies.

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